Fatemeh Javanmardi; Fakher Rahim; Amal Saki Malehi; Ahmad Ahmadzadeh; Mohamad Seghatoleslami
Volume 23, Issue 3 , 2021
Abstract
Background: In clinical cancer studies, there has been a high tendency of searching for more specific and new prognostic factors in cancers in the last few years. This multistate study aimed to model the progression of Hodgkin's disease by accounting for individual effect (heterogeneity) using the joint ...
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Background: In clinical cancer studies, there has been a high tendency of searching for more specific and new prognostic factors in cancers in the last few years. This multistate study aimed to model the progression of Hodgkin's disease by accounting for individual effect (heterogeneity) using the joint and independent frailty models.
Method: After the utilization of the illness-death model, joint-modeling accounted for the dependency between relapse and death by considering the individual characteristics as a frailty term. Therefore, the effect of influential prognostic factors was evaluated on disease progression by frailty and joint-frailty multistate models.
Results: The individual predictions were determined using the frameworks of the both models. The model was applied to 389 Hodgkin lymphoma patients. Gender (male), age (over 55 years), and low level of hemoglobin (less than 10.5) were associated with an increased risk of death and relapse in patients. The likelihood cross-validation criterion was proposed to choose the joint frailty model as a better fitting model.
Conclusion: Multistate models were appropriate tools to study the whole event history of the subjects, which provided a deep insight into the dynamics of the disease. The problem of events-subjects dependency in the survival data was clarified using the multistate model. Therefore, the heterogeneity and dependency between the states led to more accurate estimations of the effects of the prognostic factors, thereby improving the predictions.
Farideh Shishehbor; Zahra Salimi; Masood Veissi; Amal Saki Malehi; Mahdi Shiri-Nasab; Bizhan Helli
Volume 22, Issue 1 , 2020
Abstract
Background: Low Glycemic Index (GI) and high Satiety Index (SI) foods have been associated with the decreased risk of chronic diseases and obesity.
Objectives: The present study examined the effect of oak flour on GI, Glycemic Load (GL), and SI of white bread.
Methods: This randomized ...
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Background: Low Glycemic Index (GI) and high Satiety Index (SI) foods have been associated with the decreased risk of chronic diseases and obesity.
Objectives: The present study examined the effect of oak flour on GI, Glycemic Load (GL), and SI of white bread.
Methods: This randomized crossover trial was conducted at Ahvaz University of Medical Sciences, Ahvaz, Iran, during the year 2017. To determine the GI, 10 healthy subjects consumed three bread types (white bread, bread containing 25% oak flour, and bread containing 50% oak flour) and reference food (glucose) containing 50 g of carbohydrates on separate occasions. Finger-prick blood samples were collected at fasting (0 min) and at 15, 30, 45, 60, 90, and 120 min after meal consumption. To determine the SI, 20 healthy individuals consumed 240 kcal portions of test bread types (white bread, bread containing 25% oak flour, and bread containing 50% oak flour) on separate occasions. The satiety ratings were collected at fasting and every 15 min for over 2 h after food ingestion to evaluate the SI.
Results: There were no significant differences in the mean of blood glucose Incremental Areas Under the Curve (IAUC) between the test bread types (white bread: 2,883.2 ± 353.7 vs. 25% oak flour bread: 3,163.1 ± 214.7 vs. 50% oak flour bread: 3,245.1 ± 255.9) (P > 0.05). Also, no significant differences were observed between the mean of bread GIs (P > 0.05). The satiety IAUCs of both oak bread types (25% oak flour bread: 377.17 ± 59.83, 50% oak flour bread: 427.87 ± 55.46) were significantly greater than that of white bread (248.55 ± 46.45) (P < 0.001). The SI of both oak bread samples (25% oak flour bread: 202.48 ± 7.92, 50% oak flour bread: 266.25 ± 11.66) was significantly greater than that of white bread (100) (P < 0.001).
Conclusions: The addition of oak flour did not modify the GI; however, it increased the SI of white bread and created a greater feeling of satiety.
Zohreh Ahmadi; Zahra Abbaspoor; Naser Behroozy; Amal Saki Malehi
Volume 19, Issue 10 , October 2017, , Pages 1-7
Abstract
Background: Studies show that infertility can result in body image changes, which can majorly affect personality.Objectives: The current study aimed to determine the effects of cognitive behavioral therapy (CBT) on body image in infertile women.Methods: This clinical trial was performed on 24 infertile ...
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Background: Studies show that infertility can result in body image changes, which can majorly affect personality.Objectives: The current study aimed to determine the effects of cognitive behavioral therapy (CBT) on body image in infertile women.Methods: This clinical trial was performed on 24 infertile women, admitted to the Infertility Research and Treatment Center of Ahvaz, Iran in 2016-2017. In the first stage, convenience sampling was applied, and the participants were allocated to 2 groups (12 patients per group), using a table of random numbers. The experimental group participated in 10 sessions of CBT weekly, based on the 8-step program by Cash. body-self relations questionnaire and Beck Self-Concept inventory were completed in each group before, immediately after, and 1 month after the intervention.Results: After the intervention, the mean scores of body image were 156.9 ± 3.4 and 148.7 ± 4.8 in the experimental and control groups, respectively; the difference was significant (P = 0.025), and the effects persisted until the follow-up.Conclusions: CBT based on the 8-step program by Cash can improve the body image of infertile women through challenging and improving their irrational beliefs about their bodies.
